Kile developed an interest in biomarker discovery and development through his BSc in Biochemistry and Biological Chemistry at University of Nottingham.  He undertook an MSc in Medical Sciences at Newcastle University with a focus on drug discovery, experimental medicine and transplantation. This background was subsequently employed throughout a range of projects including analysis of incidence rates of graft-versus-host-disease following haematopoietic stem cell transplantation, metastatic risk stratification in squamous cell carcinoma and molecular stratification of primary biliary cholangitis. He completed a PhD in bioinformatics in 2018 from Newcastle University on data driven analysis of human dendritic cell subsets before joining the Human Cell Atlas project, working on machine learning and single cell data analysis in the area of human fetal development.

Kile joined the Newcastle MIC in February 2020 and is bringing together the experience gained through his research career in bioinformatics and experimental medicine to develop novel methodology in the field of diagnostics test evaluation.  He is also developing qualitative skills for care pathway analysis. This includes gathering and analysing views from key opinion leaders through surveys and interviews. Kile was promoted to a senior methodologist position in 2022.